Before joining the Department, Dr. Karim was a professor of chemical engineering at Texas Tech University. He has been a visiting professor at Helsinki University of Technology, Technical University of Denmark, Osaka University and the University of Newcastle upon Tyne. Trained in process control and optimization theories, he has been involved in biotechnology research for the last twenty-two years. Examples of his recent research topics are the application of on-line model predictive control of recombinant fermentations (e.g. E coli, CHO cells) and the use of data based approaches such as Neural Networks and Principal Component Analysis, to classification, fault detection and identification of bioprocesses. Dr. Karim is also involved in research areas such as lignin biodegradation and recombinant fermentation for ethanol production from mixed substrates. His recent research activities involve regulation of apoptosis in mammalian cell culture, proteomic data-analysis for metabolic pathway modification, and effects of shear stress on t-PA protein production in CHO cells. Funding for his work has come from the National Science Foundation, USAID, the Department of Energy, and the Colorado Institute for Research in Biotechnology, and various industries. He is the director of the successful short course, “Advanced Industrial Bioprocessing,” offered every year for the biotechnology industries.
Research
- Advanced Data Analysis
- Control & Optimization of Chemical and Bio-Processes
- Bio-Fuels Production Using Recombinant Microorganisms
- Metabolic Engineering
- Design & Production of Glycol-Proteins in CHO Cell Culture
- Diabetic & Cardiovascular Diseases
Education
- Ph.D., Chemical Engineering, University of Manchester Institute of Science and Technology, U.K., (1977)
- M.S., Control Engineering, University of Manchester Institute of Science and Technology, U.K., (1972)
- B.S., Chemical Engineering, Bangladesh University of Engineering and Technology, (1972)
Awards
- Holder of the Michael O’Connor Chair II
- Finalist, Fulbright Distinguished Chair position in Renewable Energy, Chalmers University, Sweden, 2008.
- Best Teacher Award, Colorado State University, 2004 – 2005
- Elected, Fellow, American Institute of Chemical Engineers, 2001
- Abell Faculty Research and Graduate Program Support Award (Best Research Award in the College), College of Engineering, Colorado State University, 1997
- Member, Third World Academy of Sciences (Lectureship), Trieste, Italy, 1994- present
- Distinguished Visiting Professor, International Center for Cooperative Research in Biotechnology, Osaka University, Osaka, Japan, 1994/95
- BBSRC (Biotechnology and Biological Sciences Research Council) Visiting Research Fellow (U.K.), 1995
Publications
Peri, S., M. L. Muthukumar, M. N. Karim, and R. S. Khare. 2012. Dynamics of Cello-oligosaccharides on Cellulose Crystal Surface. Cellulose (accepted).
Koh Y. P.,M. N. Karim, and S.L. Simon. 2012. Heterogeneous Reaction Kinetics of Epoxide-Functionalized Regenerated Cellulose Membrane and Aliphatic Amine. Thermochimica Acta, 543: 18– 23.
Alim D., J. Kim, R. H. McLean, S. A.Vanapalli, and M. N.Karim. 2012. Growth kinetics of microalgae in microfluidic static droplet array, Biotechnol. Bioengineering,published online: 18 JUN 2012 | DOI: 10.1002/bit.24568
Aldrich, J. F., E. W. Winn, M. H. Shearer1,P.Qin, M. N. Karim, and R. C. Kennedy. 2011.Progress on the Development of Universal Influenza Vaccines, Current Topics in Virology, 9: 51-58.
Nallasivam U., S. Babji, K. Vidyashankar, M. N. Karim and R. Rengaswamy. 2011. Global ARX Identification with Guaranteed Stability Using a Bilinear Reformulation. Transaction Automatic Control, 56(6): 1406-1411.
Peiyong Qin, Jie Yang, and M. Nazmul Karim. 2011 Characterization and selectivity studies of molecular imprinted membranes of Puerarin using scanning electron microscopy, Scanning, 33(1): 7-12.
Suma Peri, M. Nazmul Karim, and Rajesh Khare. 2011. Potential of Mean Force for Separation of the Repeating Units in Cellulose and Hemicellulose. Carbohydrate Research, 346 (6): 867–871
Seunghyun Ryu and Muhammad Nazmul Karim. 2011. A whole cell biocatalyst for cellulosic ethanol production from dilute acid-pretreated corn stover hydrolyzates. Applied Microbiology and Biotechnology,91(3) :529-542
Karra S, Sager B, Karim MN.2010. Multi-Scale Modeling of Heterogeneities in Mammalian Cell Culture Processes.Industrial & Engr Chem Research, 49(17): 7990-8006.